Gastric Cancer

The 2 types of gastric cancer are:

• Intestinal adenocarcinoma - Common on lesser curvature of stomach

• Diffuse adenocarcinoma - Associated with Signet cells

The most important risk factor here is Chronic H. pylori infection. Other risk factors include:

• EBV infection

• Diet - Mainly food with nitrates or salt-based preservatives (fresh fruits and vegetables are protective here)

• Smoking, Alcohol

• Autoimmune gastritis

• Inherited syndromes (rare)

Patients present with:

• IDA (iron-deficiency anaemia)

• Hx of new-onset Dyspepsia

• Early satiety (anorexia)

• Weight loss

• Progressive dysphagia

Invesitgations - Endoscopy w/biopsy, and a staging CT

Management - Surgery, chemo/radiotherapy, targeted therapy